Sds of imatinib mesylate, safety data sheets, cas 220127571. Its molecular formula is c 29 h 31 n 7 o ch 4 so 3 and its molecular weight is 589. The dose of 25 mgkg is preliminarily tested, and it produces a little improvement in lung function without statistical significance. Sigmaaldrich offers a number of imatinib mesylate products. Identification of the substancemixture and of the companyundertaking. Imatinib mesylate safety data sheet supersedes revision. Show this safety data sheet to the doctor in attendance. We conducted an openlabel, randomized, multicenter trial to evaluate the activity of imatinib in. Highlights of prescribing information these highlights do not include all the information needed to use gleevec safely and effectively. Very hazardous in case of skin contact corrosive, irritant, of eye contact irritant, of ingestion, of inhalation.
Analysis of genotoxic impurities of imatinib mesylate by lcms from early development to routine monitoring. Patients experiencing unexpected, rapid weight gain should speak to their doctor about appropriate supportive. Imatinib mesylate is a 2phenylaminopyrimidine tyrosine kinase inhibitor with specific activity for abl, platelet derived growth factor receptor, ckit, and albesonrelated gene. Identification product name imatinib mesylate cat no. Optical activity imatinib mesylate does not have chiral centers, and it is not optically active. Analysis of genotoxic impurities of imatinib mesylate by. Imatinib, free base is a free base form of imatinib mesylate cat. This document has been prepared in accordance with standards for workplace safety.
Imatinib mesylate is an offwhite to creamish yellow crystalline powder. Imatinib mesylate sti571 selectively inhibits the tyrosine kinase activity of bcrabl, ckit, and pdgfr and is successfully used for treatment of bcrabldependent chronic myelogenous and acute lymphoblastic leukemia, and ckitdependent gastrointestinal stromal tumors. First aid providers should wear personal protective equipment to prevent exposure. Understanding the molecular basis of imatinib mesylate.
Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage, we no longer display the rximage pill images associated with drug labels we anticipate reposting the images once we are able identify and filter out images that do not match the information provided in. Known hypersensitivity to imatinib or any ingredient in the formulation. The information given is designed only as a guidance for safe handling, use, processing, storage. Lenvatinib mesylate 857890392 msds report, lenvatinib mesylate msds safety technical specifications search, lenvatinib mesylate safety information specifications ect. Imatinib is a potent inhibitor of the bcrabl kinase encoded by the bcrabl oncogene as well as receptor tyrosine kinases encoded by ckit and plateletderived growth factor receptor pdgfr oncogenes. Imatinib mesylate 50 mgkg is injected intraperitoneally in the imatinib group n7, and 0.
Imatinib mesylate 21 is very soluble in water and soluble in aqueous buffers. Imatinib mesylate inhibition of bcrabl tyrosine kinase created. Solubility characteristics imatinib free base is practically insoluble in water 0. Women should be apprised of the potential harm to the fetus 5. We collect cookies for vital website function and to better serve our customers. Imatinib mesylate is a small molecule that inhibits the cabl proteintyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia cml. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Identification of the substancemixture and of the company. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors.
Pdf efficacy and safety of imatinib mesylate in advanced. Section 1 chemical product and company identification. A translocation event between chromosomes 9 and 22 generates the philadelphia chromosome, which then produces the bcrabl fusion protein with aberrant kinase activity. Disposition and biotransformation of imatinib were studied in four male healthy volunteers after a single oral dose of 239 mg of 14clabeled. Material safety data sheet article 1 identification of the substance and of the companyundertaking product name. Increase imatinib dosage by at least 50% and carefully monitor clinical response in patients receiving concomitant therapy with imatinib and potent cyp3a4 inducers e. Gleevec imatinib mesylate tablets, for oral use initial u. Identification of the substancemixture and of the companyundertaking product name. Cc1ccccc1nc2ncccn2c3cccnc3nco c4ccccc4cn5ccncc5c molecular weight. Doxazosin mesylate tablets, 8mg mysidopsis bahia mysid shrimp npdes lc50 48 hours 3. For a more detailed discussion of potential health hazards and toxicity see section 11. Ac461080050 casno 220127571 synonyms no information available recommended use laboratory chemicals. Getwell pharmaceuticals 474, udyog vihar, phasev, gurgaon 122 016, haryana, india. Imatinib mesylate is soluble in aqueous buffers less than or equal to ph 5.
The pharmacological basis of this interaction has been elucidated by crystallographic studies. Imatinib mesylate was determined by infrared absorption spectrophotometry. Efficacy and safety of imatinib mesylate in advanced. The spectrum was compared with that of imatinib mesylate rs, or with a qualified reference spectrum of imatinib mesylate.
By continuing to browse you agree to the storing of cookies on your device. Uses advised against food, drug, pesticide or biocidal product use. In addition, other severe fluid retention events e. Lenvatinib mesylate 857890392 msds, safety technical.
Safety data sheet creation date 03mar2016 revision date 23jan2018 revision number 3 1. Imatinib mesylate sti571 is a substrate for the breast. Store in accordance with information listed on the product insert. Fetal harm can occur when administered to a pregnant woman. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors article pdf available in new england journal of medicine 3477. Imatinib mesylate is a white to offwhite to brownish or yellowish tinged crystalline powder. Its 20 molecular formula is c29h31n7o ch4so3 and its relative molecular mass is 589. Safety data sheet imatinib mesylate effective date. Take this medication by mouth with a meal and a full glass of water 8 ounces240 milliliters as directed by your doctor, usually once or twice daily. The information provided in this material safety data sheet is correct to the best of our knowledge, information, and belief at the date of its publication. The information provided in this material safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. It is important that patients be weighed and monitored regularly for signs and symptoms of serious fluid retention or unexpected weight gain.
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